Regina George 2025. Mean girls's antagonist role is filled by plastics leader regina george, played in the 2025 remake by reneé rapp after rachel. Regina (2025) was just scary and mean.

There, she meets nerds and jocks, alphas and betas, and attracts the notice of the queen bee, the aptly named regina (reneé rapp, who played the role on. Reneé rapp portrayed regina george in mean girls 2025, and while regina is 16 or 17 in the film, rapp was 23 while making the movie.